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In our laboratory, we study the molecular mechanisms that regulate, control and execute developmental neuronal remodeling in Drosophila melanogaster. Remodeling refines neural circuits by a combination of degenerative processes, such as axon and synapse pruning, as well as regenerative processes, such as regrowth to form adult specific connections. Neuronal remodeling is essential for sculpting the mature nervous systems of both vertebrates and invertebrates during development. Despite its fundamental role in neurodevelopment and proposed contribution to various neuropsychiatric disorders, the mechanisms instructing remodeling are only partially known.