Munich Neuroscience Calendar


13.07.2023, 11:00 Max Planck Institute for Biological Intelligence Campus Martinsried
until 12:00
Event Type: Talk
Speaker: Erin Schuman
Institute: Max Planck Institute for Brain Research, Frankfurt/Main

Title: Local Protein Synthesis in Neurons

MPI BI, T-building, Main lecture hall
Am Klopferspitz 18
82152 Martinsried

Host: Emilie Macé
Host Email:
The complex morphology of neurons, with synapses located hundreds of microns from the cell body, necessitates the localization of important cell biological machines, including ribosomes, within dendrites and axons. Local translation of mRNAs is important for the function and plasticity of synapses. Using advanced sequencing and imaging techniques we have updated our understanding of the local transcriptome and identified the local translatome - identifying over 800 transcripts for which local translation is the dominant source of protein. In addition, we have explored the unique mechanisms neurons use to meet protein demands at synapses, identifying surprising features of neuronal and synaptic protein synthesis.

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