Event:

Please join us for a talk by Prof. Tracy Cui of the University of Pittsburgh, who runs the Neural Tissue/Electrode Interface Lab. Her talk is entitled: Materials strategies towards chronic and multimodal neural interfaces. (Full abstract below). Prof. Cui is the leader of the field of studying biological responses to neural implants.


Speaker Bio:

Prof. Tracy Cui is the William Kepler Whiteford Professor of Bioengineering at the University of Pittsburgh. She earned her Ph.D. in Macromolecular Science and Engineering from the University of Michigan. She works in the field of neural engineering with special focuses on neural electrode-tissue interface, neural tissue engineering, drug delivery, and biosensors. She has an H index of 62 with over 13,000 citations and 7 patents. Prof. Cui has won numerous awards, including the 2016 Fellow of the American Institute of Medical and Biological Engineering, the 2015 Carnegie Science Emerging Female Scientist Award, the 2008 NSF Career Award, and the 2005 Wallace Coulter Translational Research Career Award.

Abstract:
Microelectrode array (MEA) devices, placed in the nervous system to record and modulate neuroactivity have demonstrated success in neuroscience research and neural prosthesis applications. Functionalizing the microelectrode sites on MEAs to enable neurochemical sensing and drug delivery adds additional dimensions of information exchange and presents tremendous potential for understanding neural circuits and treating neurological diseases. In this talk, I will introduce the methods by which we enable chemical sensing and delivery from MEAs. By incorporating nanocarbon into the conducting polymer electrode coating, we achieved direct detection of electroactive species such as dopamine and serotonin. By immobilizing enzymes or aptamers on nanostructured electrodes, we achieved multisite detection of glutamate, GABA, and cocaine. By incorporating nanocarriers into conducting polymer coating, we enabled on-demand drug delivery. We demonstrated in vivo multisite and multiple analyte detection or neurotransmitter delivery along with neural recording from our multimodal neural probes. To overcome the challenges in the chronic neural interface, we use quantitative histology, explant analysis, and 2-photon imaging to uncover the mechanism of sensing/recording performance degradation and reveal biofouling, inflammatory host response, as well as material degradations. We use several bioengineering strategies to minimize these failure modes. First, materials and devices that mimic the mechanical properties of the neural tissue have been shown to significantly improve device-tissue integration. Secondly, biomimetic coatings and drug delivery have been applied to reduce biofouling, sensor degradation, and inflammatory responses. These approaches may be combined to achieve long-term and high-fidelity multimodal neural interfacing.