Munich Neuroscience Calendar


11.06.2024, 11:00 Max Planck Institute for Biological Intelligence Campus Martinsried
until 12:00
Event Type: Talk
Speaker: Egemen Agi
Institute: FU Berlin

Title: Axonal self-sorting without target guidance in Drosophila visual map formation

MPI BI, Seminar room NQ105
Am Klopferspitz 18
82152 Martinsried

Host: Cemre Coskun, Aisha Ali Haji

The idea of guidance towards a target is central to axon pathfinding and brain wiring in general. In this study, we show how several thousand axonal growth cones self-pattern without target-dependent guidance, even in an ectopic brain region, during neural superposition wiring in Drosophila. Ablation of all target lamina neurons or loss of target adhesion prevents the stabilization, but not the development of the pattern. Intravital imaging at the spatiotemporal resolution of growth cone dynamics in intact pupae and data-driven dynamics simulations reveal a mechanism by which more than 30.000 filopodia do not explore potential targets, but instead simultaneously generate and navigate a dynamic filopodial meshwork that steers growth directions. Hence, a guidance mechanism can emerge from the local interactions of the axons being guided, suggesting self-organization as a more general feature of brain wiring.

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