Event:

Memories shape everyday behaviour, typically informing effective responses but sometimes driving maladaptive ones. These memory-guided behaviours engage complex patterns of neuronal activity in distributed brain’s networks, including the hippocampus and its directly connected circuits. What features of neural activity underlie memory-guided behaviour?
By considering spatio-temporally organised spike discharges and rhythmic fluctuations of the local field potentials, I will discuss in this talk recent findings that describe population-level patterns of activity supporting hippocampal information processing with relevance to memory. Notably, I will present cell-type-selective and input-defined interventions that allow drawing causal involvement of neural mechanisms at the nexus of brain and behaviour, or preventing the expression of unwanted memories for rebalancing behavioural responses. Altogether, these data will highlight how fine-grained neural dynamics in the hippocampus and connected circuits promote memory-guided behaviour, for better or worse.